Last night, I reached that stage with Star Wars: Knights of the Old Republic. To avoid posting spoilers, I'll just say that the majority of the plot revolves around exploring five or six different worlds in search of the different pieces of a large puzzle, with occasional forays into subquests unrelated to the main plot. One such subquest involves a box that you're supposed to carry from one shady character to another, while under no, no, NO circumstances are you supposed to open it! You're perfectly safe as long as you don't open it! Keep it shut!
This, of course, is a big ol' setup to make you go "Oooh, what's in it, gotta open it!" But as I arrived at this subquest on the last world I was exploring, my character is something like 18th level, and I just want to get to the END of the silly thing, what did I do?
I took the box to the other shady character, and didn't open it. So now I'll never know what's in it, unless I read it off a walkthrough page or something. But honestly, I don't care. I've reached the "Get ON with it!" stage for this game, and I'm glad ... hopefully I'll get to the end soon and I can put it away. I've got other things I need to be spending my time and attention on!